Structural Characterization and Kinetics of Nitric-oxide Synthase Inhibition by Novel N5-(Iminoalkyl)- and N5-(Iminoalkenyl)-ornithines

Contrasting effects of N5-substituted tetrahydrobiopterin derivatives on phenylalanine hydroxylase, dihydropteridine reductase and nitric oxide synthase.

Tetrahydrobiopterin [(6R)-5,6,7,8-tetrahydro-L-biopterin, H(4)biopterin] is one of several cofactors of nitric oxide synthases (EC 1.14.13.39). Here we compared the action of N(5)-substituted derivatives on recombinant rat neuronal nitric oxide synthase with their effects on dihydropteridine reductase (EC 1.6.99.7) and phenylalanine hydroxylase (EC 1.14.16.1),the well-studied classical H(4)biop...

ENANO n5 requeteok.qxd

Structure of N5-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracis.

The apo structure of N5-carboxyaminoimidazole ribonucleotide synthase (PurK) from Bacillus anthracis (baPurK) with Mg2+ in the active site is reported at 1.96 Å resolution. PurK is an enzyme in the purine-biosynthetic pathway, unique to prokaryotes, that converts 5-aminoimidazole ribonucleotide to N5-carboxyaminoimidazole ribonucleotide and has been suggested as a potential antimicrobial drug t...

Embedding of N5 and the contiguous degrees

Downey and Lempp 8] have shown that the contiguous computably enumerable (c.e.) degrees, i.e. the c.e. Turing degrees containing only one c.e. weak truth-table degree, can be characterized by a local distributivity property. Here we extend their result by showing that a c.e. degree a is noncontiguous if and only if there is an embedding of the nonmodular 5-element lattice N5 into the c.e. degre...

proteinuria is reduced by inhibition of inducible nitric oxide synthase in rat renal ischemia/reperfusion injury

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